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Title of Journal: Eur J Pediatr

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Abbravation: European Journal of Pediatrics

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Springer-Verlag

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DOI

10.1002/bjs.1800741021

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1432-1076

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Clinical practice

Authors: Gema Ariceta
Publish Date: 2010/11/10
Volume: 170, Issue: 1, Pages: 15-20
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Abstract

Proteinuria detection in children is a challenge Five percent to 15 and 04–1 of school children present either transient benign or persistent increased amount of protein in urine respectively Persistent proteinuria constitutes not only a sign of overt kidney disease but may also be the first indicator of silent renal damage Proteinuria is a marker for hyperfiltration in individuals with reduced nephron mass and one of the most important independent risk factor for renal disease progression as well It constitutes the single most important risk factor for future loss of kidney function preceding glomerular filtration rate reduction Further proteinuria itself is diagnostic of cardiovascular disease with prognostic value and target organ involvement in highrisk populations such as diabetic obese hypertensive children or those with known reduced renal mass or previous renal injury Current strategies to prevent CKD progression a concept known as renoprotection are focused on reducing urinary protein excretion among other factors Reversibility of organ damage in early stages is possible therefore pediatricians should screen children for proteinuria or microalbuminuria mainly in highrisk groups

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