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Title of Journal: Eur J Pediatr

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Abbravation: European Journal of Pediatrics

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Springer-Verlag

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DOI

10.1002/cite.330311212

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1432-1076

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Primary carebased surveillance to estimate the bu

Authors: Javier DiezDomingo JoseMaria Baldo Marian Patrzalek Petr Pazdiora Johannes Forster Luigi Cantarutti JeanYves Pirçon Montse SorianoGabarró Nadia Meyer on behalf of the SPRIK Rotavirus Study Group
Publish Date: 2010/09/15
Volume: 170, Issue: 2, Pages: 213-222
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Abstract

This observational prospective study was undertaken to estimate the burden of rotavirus RV gastroenteritis GE leading to general practitioner GP/family paediatrician FP visits among children aged 5 years in Czech Republic Germany Italy Poland Spain and the UK Children aged 5 years presenting with acute GE provided stool samples for rapid RV testing RV+ samples were confirmed and typed by RTPCR Demographic and clinical data were collected for all RVGE episodes Transmission patterns among other household children aged 5 years were also assessed From November 2005 to May 2007 excluding data from the UK 497/3813 130 children aged 5 years presenting with acute GE to GP/FP and tested were RV+ by PCR Most RVGE cases 691 occurred in children aged 2 years occurred between December and May 931 and were moderate or severe by Vesikari score 929 RV strain distribution varied between countries G9P8 was the most common type in Poland 54/76 and Spain 172/196 G1P8 was predominant in the Czech Republic 56/64 and Italy 46/107 and G4P8 and G1P8 both prevailed in Germany 17/54 and 13/54 respectively A total of 24/122 197 children aged 5 years resident in the same household as a PCR+ study participant also developed RVGE Conclusion This multinational epidemiological study in Europe shows that RV is easily transmitted among household children with RVGE burden highest among children aged 2 years accessing primary healthcare for acute GEJulia Colomer Spain Isabel Ubeda Spain Trinidad AlvarezLaviada Spain Mercedes Garcia Spain Angels Jubert Spain María Garcés Spain Carmen Peidró Spain Victoria Planelles Spain Carmen Casani Spain Giacomo Toffol Italy Silvia Carnazza Italy Milada Nova Czech Republic Lenka Prachova Czech Republic Dana Kabzanova Czech Republic Iva Kubiasova Czech Republic Jirina Rusinova Czech Republic Pavla Sandova Czech Republic Dagmar Valeckova Czech Republic Veronika Nova Czech Republic Johann Disselhoff Germany Ulrich Behre GermanyThis study was funded by GlaxoSmithKline Biologicals The study sponsor designed the study in collaboration with investigators and coordinated data gathering analysis and interpretation and writing of the report Authors had full access to all study data and final responsibility for the decision to submit for publication

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