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Title of Journal: Eur J Pediatr

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Abbravation: European Journal of Pediatrics

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Springer Berlin Heidelberg

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DOI

10.1007/s11042-012-1187-9

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1432-1076

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Changes in the incidence and etiology of congenita

Authors: Katarina Mitrovic Rade Vukovic Tatjana Milenkovic Sladjana Todorovic Jovana Radivojcevic Dragan Zdravkovic
Publish Date: 2015/09/07
Volume: 175, Issue: 2, Pages: 253-259
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Abstract

Congenital hypothyroidism CH is the most frequent congenital endocrine disorder The purpose of the present study was to determine the incidence of CH in Central Serbia from 1983 to 2013 Newborn screening for CH was based on measuring neonatal thyroidstimulating hormone TSH using a 30 mU/l cutoff CO until 12/1987 P1 15 mU/l until 12/1997 P2 10 mU/l until 12/2006 P3 and 9 mU/l thereafter P4 During the study period there were 1547122 live births screened for CH Primary CH was detected in 434 newborns with incidence of 13728 With gradual lowering of the CO the incidences of CH increased from 15943 in P1 to 11872 in P4 p  0001 Incidence of CH with ectopic and enlarged gland doubled p  0001 while prevalence of athyreosis remained relatively constant The most prominent finding was the increase in the transient CH from none in P1 to 35  of all CH patients in P4

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