Authors: Enrico Valerio Marta Rossella Valente Sabrina Salvadori Anna Chiara Frigo Eugenio Baraldi Paola Lago
Publish Date: 2016/05/05
Volume: 175, Issue: 7, Pages: 953-966
Abstract
Increasing recent evidence favors paracetamol use for patent ductus arteriosus PDA closure in preterms Our study aims were 1 to assess efficacy and safety of intravenous iv paracetamol for PDA closure in a 23–32week preterm population as “firstline” when traditional ibuprofen treatment was contraindicated or “rescue” treatment after ibuprofen failed and 2 to identify predictors of PDA closure The cumulative efficacy of consecutive cycles of iv paracetamol on PDA closure was confirmed after both “firstline” and “rescue” treatment the overall PDA closure rates being respectively 567 and 611 p = 07624 after two cycles and 633 and 778 p = 02959 after three cycles No toxicity was apparent after either “firstline” or “rescue” iv paracetamol treatment On multivariate analysis gestational age GA emerged as an independent predictor of PDA closure in the “firstline” iv paracetamol treatment group while clinical risk index for babies CRIB score a patient risk index based on birth weight GA at birth sex patient’s temperature on admission and maximum base excess in first 12 h of life was an independent predictor of PDA closure failure in the “rescue” group
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