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Title of Journal: Eur J Pediatr

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Abbravation: European Journal of Pediatrics

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Springer-Verlag

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DOI

10.1016/0030-4018(93)90735-n

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1432-1076

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Desferrioxamine treatment of iron overload seconda

Authors: Mehmet Yalaz Betül Siyah Bilgin Ozge Altun Köroğlu Yılmaz Ay Ciğdem Arıkan Sermet Sagol Mete Akısü Nilgün Kültürsay
Publish Date: 2011/07/07
Volume: 170, Issue: 11, Pages: 1457-
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Abstract

Intrauterine transfusion is the standard of care in the management of severe Rh isoimmunization Desferrioxamine has been used for the treatment of iron overload secondary to hemolysis and intrauterine transfusions in Rh isoimmunization cases Here we report a preterm infant born at 34 weeks of gestational age who had formerly received intrauterine transfusions for Rhesus hemolytic disease and presented with severe hyperferritinemia and elevated liver enzymes in the first week of life Desferrioxamine treatment was started due to a ferritin level of 28800 ng/ml and continued for 13 weeks Although the treatment was successful we observed resistant leukopenia which resolved after the cessation of treatment In conclusion iron overload secondary to intrauterine transfusions can be treated successfully with desferrioxamine however neonatologists must be aware of the possible side effects of this drug which has been used in only a limited number of newborns

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