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Title of Journal: Eur J Pediatr

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Abbravation: European Journal of Pediatrics

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Springer-Verlag

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10.1007/bf00314496

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1432-1076

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Emphasis Type="Italic"BTNL2/Emphasis gene poly

Authors: KaiChung Hsueh YingJu Lin JengSheng Chang Lei Wan FuuJen Tsai
Publish Date: 2009/11/01
Volume: 169, Issue: 6, Pages: 713-719
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Abstract

The butyrophilinlike 2 BTNL2 gene is a member of the B7 receptor family that probably functions as a T cell costimulatory molecule Because altered T cell functions are implicated in dysregulation of the immune response seen in Kawasaki disease KD it is reasonable to speculate that BTNL2 gene is involved in the pathophysiology of KD The purpose of this study was to investigate whether polymorphisms of the BTNL2 gene are associated with KD and the development of coronary artery lesions CALs in Taiwanese children Ninethree patients with KD and 669 ethnically matched healthy controls were genotyped for BTNL2 gene rs1555115 C/G and rs2395158 A/G polymorphisms The frequency of GG genotype of rs 1555115 was significantly higher in KD patients compared with controls 22 vs 02 P = 0012 The odds ratio for developing KD in individuals with rs 1555115 GG genotype was 147 95 confidence interval 204–1055 P = 0003 compared with individuals with rs 1555115 CG and CC genotypes No significant difference was observed in the genotype and allelic frequencies of rs 2395158 polymorphism between KD patients and controls However the frequency of the G allele of rs 2395158 was significantly higher in KD patients with CALs than in those without CALs P = 0001 No significant difference was observed in the genotype and allelic frequencies of rs 1555115 polymorphism between KD patients with and without CALs In conclusion our results suggest that BTNL2 gene polymorphisms might be genetic markers of KD susceptibility and risk of coronary artery complication in Taiwanese children

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