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Title of Journal: Neurochem Res

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Abbravation: Neurochemical Research

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Springer US

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DOI

10.1007/s11069-015-1692-z

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1573-6903

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DARPP32 and NCS1 Expression is not Altered in Br

Authors: Bruno R Souza Bernardo S Motta Daniela V F Rosa Karen C L Torres Adalberto A Castro Clarissa M Comim André M Sampaio Fabrício F Lima Andreas Jeromin João Quevedo Marco A RomanoSilva
Publish Date: 2007/08/31
Volume: 33, Issue: 3, Pages: 533-538
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Abstract

Dopaminemediated neurotransmission imbalances are associated with several psychiatry illnesses such as schizophrenia Recently it was demonstrated that two proteins involved in dopamine signaling are altered in prefrontal cortex PFC of schizophrenic patients DARPP32 is a key downstream effector of intracellular signaling pathway and is downregulated in PFC of schizophrenic subjects NCS1 is a neuronal calcium sensor that can inhibit dopamine receptor D2 internalization and is upregulated in PFC of schizophrenic subjects It is well known that dopamine D2 receptor is the main target of antipsychotic Therefore our purpose was to study if chronic treatment with typical or atypical antipsychotics induced alterations in DARPP32 and NCS1 expression in five brain regions prefrontal cortex hippocampus striatum cortex and cerebellum We did not find any changes in DARPP32 and NCS1 protein expression in any brain region investigated

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