Authors: C N Randall D Strasburger J Prozonic S N Morris A D Winkie G R Parker D Cheng E M Fennell I Lanham N Vakil J Huang H Cathcart R Huang S E Poduslo
Publish Date: 2008/02/29
Volume: 34, Issue: 1, Pages: 23-28
Abstract
Multiple genetic variants may contribute to the risk of developing Alzheimer’s disease We have analyzed polymorphisms in 9 genes to determine whether particular combinations would contribute to this risk The genes were APOE LDLr CST3 CTSD TNF BACE1 MAPT STH eNOS and TFCP2 Three risk groups for the disease were identified Risk group I was younger was heterozygous for the CST3 GA CTSD2936 AG TNF 308 AG genetic variants Risk group II was older was homozygous for the −427 APOE promoter polymorphism TT and heterozygous for the MAPT deletion and for the STH variant QR Group III had both the youngest and oldest subjects were heterozygous for the −863 AC and −1031 CT TNF promoter polymorphisms All three groups carried the APOE 4 allele and were heterozygous for both BACE1 polymorphisms The control groups were carriers of the APOE 3 allele and were homozygous for the BACE1 genetic variantsThe authors thank the Texas and Georgia families for participating in the DNA Bank DNA was also obtained from the National Cell Repository for Alzheimer’s disease supported by the cooperative agreement grant U24AG21886 The research was supported by MCG startup funds the summer STAR program and a VA Merit Award
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