Authors: Bernard P Roques Florence Noble
Publish Date: 2013/03/21
Volume: 21, Issue: 11, Pages: 1397-1410
Abstract
The overlapping distribution of opioid and cholecystokinin CCK peptides and their receptors μ and δ opioid receptors CCKA and CCKB receptors in the central nervous system have led to a large number of studies aimed at clarifying the functional relationships between these two neuropeptides Most of the pharmacological studies devoted to the role of CCK and enkephalins have been focused on the control of pain Recently the existence of regulatory mechanisms between both systems have been proposed and the physiological antagonism between CCK and endogenous opioid systems has been definitely demonstrated by coadministration of CCKB selective antagonists with RB 101 a systemically active inhibitor which fully protects enkephalins from their degradation Several studies have also been done to investigate the functional relationships between both systems in development of opioid sideeffects and in behavioral responses This article will review the experimental pharmacology of association of enkephalindegrading enzyme inhibitors and CCKB antagonists to demonstrate the interest of these molecules in the management of both pain and opioid addiction
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