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Title of Journal: Neurochem Res

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Abbravation: Neurochemical Research

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Springer US

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DOI

10.1016/0167-5699(92)90144-v

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ISSN

1573-6903

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Protective Effect of Granulocyte Colonystimulatin

Authors: Lei Zhang XiJi Shu HongYan Zhou Wei Liu Ying Chen CuiLan Wang Yan li QiongXia Chen LiJiang Liu JianZhi Wang
Publish Date: 2009/01/24
Volume: 34, Issue: 7, Pages: 1317-
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Abstract

Granulocyte colonystimulating factor GCSF is a member of the cytokine family of growth factors that can protect the neurons from focal cerebral ischemiainduced injuries The intracerebral hemorrhage ICH has been widely observed in the clinic however the protective effect of GCSF on ICH is still elusive We found in the present study that the intraperitoneal injection of GCSF for 5 days could improve the ICHinduced neuronal behavioral impairment measured by limb placement assay We also observed that injection of GCSF could increase the number of stem cells in the specific zone of the hemorrhagic areas demonstrated by the enhanced expression of nestin Additionally GCSF could also promote the mobilization of circulating hemopoietic stem cells HSCs to the damaged brain areas and activate the astrocytes Our results reveal that GCSF is also protective for the ICH with the mechanisms involving proliferation of neural stem cells the migration of HSCs and the activation of astrocytes

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