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Title of Journal: Neurochem Res

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Abbravation: Neurochemical Research

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Springer US

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DOI

10.1016/0141-9382(88)90084-4

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1573-6903

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Dopamine Content in the Striatum and Expression Ch

Authors: ZhengQuan Yu MeiYing Liu QingXian Ren Ye Xiong JianHui Xu ChengHua Xiao DianShuai Gao
Publish Date: 2011/08/05
Volume: 36, Issue: 12, Pages: 2333-
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Abstract

To determine the dopamine DA content in the striatum and the expression changes of the apoptosisassociated proteins Bad and Bcl2 in the substantia nigra compacta SNc in elderly rats with abnormal behavior Fifty three Sprague–Dawley rats were divided into three groups adult agemotorplus normal behavior and agedmotorminus abnormal behavior using the hanger test The DA content in the striatum and the expression of tyrosine hydroxylase TH Bad and Bcl2 in the SNc were measured by HPLC/MS high performance liquid chromatogram–mass spectra and Western Blot 1 The results from the hanger test demonstrated that the scores and latency of agedmotorminus group were lower than the agemotorplus group 2 Results from HPLCMS showed that compared with the agemotorplus and adult group the content of DA in elderly rat striata decreased significantly with a statistically significant difference 3 The Western Blot demonstrated that compared with the adults the expression of TH in elderly rats significantly decreased but the difference was not significant between the agedmotorminus group and the agemotorplus group Compared with the agemotorplus and the adult group the expression of Bad increased but Bcl2 decreased in the agedmotorminus group The decrease in TH content in the SNc correlated with the aging of rats The decrease in DA content in the striatum may correlate with the abnormal behavior in elderly rats which could be ascribed to the variations in Bad and Bcl2

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