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Title of Journal: Neurochem Res

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Abbravation: Neurochemical Research

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Springer US

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DOI

10.1007/s003590050197

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1573-6903

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Heat shock protein 60 affects behavioral improveme

Authors: Can Zhao Hui Li XianJing Zhao ZhengXia Liu Ping Zhou Ying Liu MeiJiang Feng
Publish Date: 2016/01/12
Volume: 41, Issue: 6, Pages: 1238-1249
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Abstract

Parkinson’s disease PD is a neurodegenerative disorder that is caused by a loss of dopaminergic DAergic neurons in mesencephalic substantia nigra SN Human umbilical cord mesenchymal stem cells hUCMSCs are capable of selfrenewal and differentiation into multiple cell lineages including DAergic neurons Thus hUCMSCs could be a promising alternative to compensate for the loss of DAergic neurons in PD In the current study hUCMSCs and hUCMSCsderived DAergiclike neurons were transplanted into the striatum and SN of a rat model of PD that is induced by 6hydroxydopamine 6OHDA We evaluated their therapeutic effects on improving rotation behavior in the rat and on modulating the level of heat shock protein 60 Hsp60 expression in the brain After transplantation an amelioration of rotation behavior was observed in rats that underwent cell grafting and hUCMSCsderived DAergiclike neurons were superior to hUCMSCs at inducing behavioral improvement Western blot and immunohistochemistry analysis indicated significantly elevated levels of Hsp60 in cellgrafted rats compared to 6OHDAlesioned PD rats These results demonstrate that hUCMSCsbased cell transplantation is potential therapeutic treatment for PD and hUCMSCsderived DAergiclike neurons appear to be favorable candidates for cell replacement therapy in PD Finally Hsp60 could be involved in a mechanism of behavioral recovery

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