Journal Title
Title of Journal: Neurochem Res
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Abbravation: Neurochemical Research
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Authors: R M Aroutiounian G G Hovhannisyan G H Gasparyan K S Margaryan D N Aroutiounian N K Sarkissyan A A Galoyan
Publish Date: 2010/05/25
Volume: 35, Issue: 6, Pages: 953-953
Abstract
A new prolinerich polypeptide PRP1 has been earlier shown to possess a broad spectrum of biological activities and seems to be a potential medicine The potential genotoxic properties of PRP1 and protective effect of PRP1 against genotoxic action of Mitomycin C MMC were analyzed in details in the present work DNA and chromosome damages were studied in KCL22 cell line of human myeloid leukemia by the Comet assay and micronucleus induction test respectively The results suggest that DNA damages are at least partly transient and reparable PRP1 at the doses 05–20 l g/ml does not possess genotoxic activity Moreover this peptide expresses both preventive and therapeutic effects against MMCinduced DNA damage Pretreatment of cells with PRP1 also prevents the appearance of daughter cells bearing as heavy MMCinduced DNA/chromosome damages as MNs Thus the polypeptide studied is able to protect the cells from genotoxic action of MMC This defense includes not only DNA but also heritable chromosome damage in postmitotic cells Possible mechanisms of PRP1 protective action are discussedFor reasons that are beyond the control of the authors and journal editors the article titled “Prolinerich Polypeptide1 Protects the Cells In Vitro from Genotoxic Effects of Mitomycin C” by R M Aroutiounian G G Hovhannisyan G H Gasparyan K S Margaryan D N Aroutiounian N K Sarkissyan A A Galoyan DOI 101007/s1106400901048 was published in the regular issue Vol 35 issue 4 instead of this special issue where it was originally scheduled to appear
Keywords:
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