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Title of Journal: Neurochem Res

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Abbravation: Neurochemical Research

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Springer US

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DOI

10.1016/0891-3919(57)90187-0

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1573-6903

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Early Temporal Changes in EctoNucleotidase Activi

Authors: Nadezda Nedeljkovic Ivana Bjelobaba Irena Lavrnja Danijela Stojkov Sanja Pekovic Ljubisav Rakic Mirjana Stojiljkovic
Publish Date: 2007/11/10
Volume: 33, Issue: 5, Pages: 873-879
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Abstract

During a variety of insults to the brain adenine nucleotides are released in large quantities from damaged cells triggering multiple cellular responses to injury Here we evaluated changes in extracellular ATP ADP and AMP hydrolysis at different times 0–24 hours after unilateral cortical stab injury CSI in adult rats Results demonstrated that 24 hours following CSI ATP and ADP hydrolyzing activities were not significantly altered in injured cortex Based on calculated V ATP/V ADP ratio it was concluded that ATP/ADP hydrolysis was primarily catalyzed by NTPDase1 enzyme form In contrast AMP hydrolysis catalyzed by 5’nucleotidase was significantly reduced at least 4 hours following CSI Kinetic analysis and LineweaverBurk transformation of the enzyme velocities obtained over the range of AMP concentrations 005–150 mM revealed that inhibition of 5’nucleotidase activity after CSI was of the uncompetitive type Taken together our data suggest that injured tissue has reduced potential for extracellular metabolism of adenine nucleotides in early stages after CSI

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