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Title of Journal: Neurochem Res

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Abbravation: Neurochemical Research

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Springer US

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1573-6903

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Neurotrophic Effects of GnRH on Neurite Outgrowth

Authors: J Luis Quintanar Eva Salinas
Publish Date: 2007/12/20
Volume: 33, Issue: 6, Pages: 1051-1056
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Abstract

The presence of GnRH receptor in cerebral cortical neurons of rat embryos and adult rats has been described In this work we studied the effects of GnRH on outgrowth and length of neurites and cytoskeletal neurofilament proteins expression NF68 and NF200 kDa by immunoblot of cultured cerebral cortical neurons of rat embryos Our results show that GnRH increases both outgrowth and length of neurites accompanied by an increase in neurofilaments expression It is conceivable that GnRH plays a role in neuronal plasticity parallel to its gonadal functionWe express our sincere gratitude to Dr Kalman Kovacs and Dr Andrés Quintanar Stephano for reviewing the manuscript and AQB María del Rosario Montoya Dra Madel Rosario Campos Biól Rebeca Corona Cecilia Magaña and TLQ Gabriela Orozco for their participation in the experiments We also thank to MVZ José Luis Ponce for providing the animals from animal room UAA

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