Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Neurochem Res

Search In Journal Title:

Abbravation: Neurochemical Research

Search In Journal Abbravation:

Publisher

Springer US

Search In Publisher:

DOI

10.1016/0008-6215(93)84059-f

Search In DOI:

ISSN

1573-6903

Search In ISSN:
Search In Title Of Papers:

An NCAM Mimetic FGL Alters Hippocampal Cellular

Authors: Bunmi Ojo Paul L Gabbott Payam Rezaie Nicola Corbett Nikolay I Medvedev Thelma R Cowley Marina A Lynch Michael G Stewart
Publish Date: 2012/10/18
Volume: 38, Issue: 6, Pages: 1208-1218
PDF Link

Abstract

The neural cell adhesion molecule NCAM is ubiquitously expressed within the CNS and has roles in development cognition neural plasticity and regulation of the immune system NCAM is thus potentially an important pharmacological target for treatment of brain diseases A cell adhesion mimetic FGL a 15 aminoacid peptide derived from the second fibronectin typeIII module of NCAM has been shown to act as a neuroprotective agent in experimental disease and ageing models restoring hippocampal/cognitive function and markedly alleviating deleterious changes in the CNS However the effects of FGL on the hippocampus of young healthy rats are unknown The present study has examined the cellular neurobiological consequences of subcutaneous injections of FGL on hippocampal cell morphometry in young 4 monthold rats We determined the effects of FGL on hippocampal volume pyramidal neuron number/density using unbiased quantitative stereology and examined aspects of neurogenesis using 2D morphometric analyses FGL treatment reduced total volume of the dorsal hippocampus associated with a decrease in total pyramidal neuron numbers in CA1 and CA3 and elevated the number of doublecortin immunolabeled neurons in the dentate gyrus indicating a likely influence on neurogenesis in young healthy rats These data indicate that FGL has a specific age dependent effect on the hippocampus differing according to the development and maturity of the CNS

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Demonstration of Neuron-Glia Transfer of Precursors for Gaba Biosynthesis in a Co-Culture System of Dissociated Mouse Cerebral Cortex
  2. Naringin Treatment Improves Functional Recovery by Increasing BDNF and VEGF Expression, Inhibiting Neuronal Apoptosis After Spinal Cord Injury
  3. Neonatal Handling, Sweet Food Ingestion and Ectonucleotidase Activities in Nucleus Accumbens at Different Ages
  4. Spatial Organization and Stoichiometry of N-Terminal Domain-Mediated Glycosyltransferase Complexes in Golgi Membranes Determined by Fret Microscopy
  5. Erratum to: Studying Human Brain Inflammation in Leptomeningeal and Choroid Plexus Explant Cultures
  6. Association of enkephalin catabolism inhibitors and CCKB antagonists: A potential use in the management of pain and opioid addiction
  7. Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells
  8. DARPP-32 and NCS-1 Expression is not Altered in Brains of Rats Treated with Typical or Atypical Antipsychotics
  9. Heat shock protein 60 affects behavioral improvement in a rat model of Parkinson’s disease grafted with human umbilical cord mesenchymal stem cell-derived dopaminergic-like neurons
  10. Simvastatin Attenuates Neuropathic Pain by Inhibiting the RhoA/LIMK/Cofilin Pathway
  11. Chronic Phencyclidine Induces Inflammatory Responses and Activates GSK3β in Mice
  12. Antiamnesic Effect of B. monniera on L-NNA Induced Amnesia Involves Calmodulin
  13. The Role of Glutamine Synthetase and Glutamate Dehydrogenase in Cerebral Ammonia Homeostasis
  14. Taurine Protected Against the Impairments of Neural Stem Cell Differentiated Neurons Induced by Oxygen–Glucose Deprivation
  15. The Similar Expression Pattern of MHC Class I Molecules in Human and Mouse Cerebellar Cortex
  16. Novel Structure–Function Information on Biogenic Amine Transporters Revealed by Site-Directed Mutagenesis and Alkylation
  17. Lysophosphatidic Acid can Support the Formation of Membranous Structures and an Increase in MBP mRNA Levels in Differentiating Oligodendrocytes
  18. The Role of Nitric Oxide in the Neuroprotection of Limb Ischemic Preconditioning in Rats
  19. Protective Effect of Shikonin in Experimental Ischemic Stroke: Attenuated TLR4, p-p38MAPK, NF-κB, TNF-α and MMP-9 Expression, Up-Regulated Claudin-5 Expression, Ameliorated BBB Permeability
  20. Proline-Rich Polypeptide-1 Protects the Cells In Vitro from Genotoxic Effects of Mitomycin C
  21. Kalirin-7, a Protein Enriched in Postsynaptic Density, is Involved in Ischemic Signal Transduction
  22. Relationship of Adult Neurogenesis with Tau Phosphorylation and GSK-3β Activity in Subventricular Zone
  23. Role of Tuberin in Neuronal Degeneration
  24. Brain Iron Toxicity: Differential Responses of Astrocytes, Neurons, and Endothelial Cells
  25. Humanin Protects Cortical Neurons from Ischemia and Reperfusion Injury by the Increased Activity of Superoxide Dismutase
  26. Reduced Glutamate Release in Adult BTBR Mouse Model of Autism Spectrum Disorder
  27. Pore Structure of the Cys-loop Ligand-gated Ion Channels
  28. Neurotrophic Effects of GnRH on Neurite Outgrowth and Neurofilament Protein Expression in Cultured Cerebral Cortical Neurons of Rat Embryos
  29. Salvianolic Acid A Exerts Antiamnesic Effect on Diazepam-Induced Anterograde Amnesia in Mice
  30. GABA A -R α4 Subunits are Required for the Low Dose Locomotor Stimulatory Effect of Alphaxalone, But Not for Several Other Behavioral Responses to Alphaxalone, Etomidate or Propofol
  31. Early Temporal Changes in Ecto-Nucleotidase Activity after Cortical Stab Injury in Rat
  32. The Expression Pattern of Classical MHC Class I Molecules in the Development of Mouse Central Nervous System
  33. Does Global Astrocytic Calcium Signaling Participate in Awake Brain State Transitions and Neuronal Circuit Function?
  34. Dopamine Content in the Striatum and Expression Changes of Bad and Bcl-2 in Elderly Rats with Abnormal Behavior
  35. Dopamine as a Potent Inducer of Cellular Glutathione and NAD(P)H:Quinone Oxidoreductase 1 in PC12 Neuronal Cells: A Potential Adaptive Mechanism for Dopaminergic Neuroprotection
  36. An Analytical Flow Injection System to Measure Glutamate in Microdialysis Samples Based on an Enzymatic Reaction and Electrochemical Detection
  37. Protective Effect of Granulocyte Colony-stimulating Factor on Intracerebral Hemorrhage in Rat
  38. Role of Telomerase Reverse Transcriptase in Glial Scar Formation After Spinal Cord Injury in Rats
  39. Cluster Analysis of Risk Factor Genetic Polymorphisms in Alzheimer’s Disease
  40. Comparison of Glutamate Turnover in Nerve Terminals and Brain Tissue During [1,6- 13 C 2 ]Glucose Metabolism in Anesthetized Rats
  41. Comparison of Glutamate Turnover in Nerve Terminals and Brain Tissue During [1,6- 13 C 2 ]Glucose Metabolism in Anesthetized Rats
Search Result: