Authors: Shenghua Zhu Hongxing Wang Ruoyang Shi Ruiguo Zhang Junhui Wang Lynda Kong Yingxia Sun Jue He Jiming Kong JunFeng Wang XinMin Li
Publish Date: 2014/10/01
Volume: 39, Issue: 12, Pages: 2385-2393
Abstract
Use of phencyclidine PCP in rodents can mimic some aspects of schizophrenia However the underlying mechanism is still unclear Growing evidence indicates that neuroinflammation plays a significant role in the pathophysiology of schizophrenia In this study we focused on inflammatory responses as target of PCP for inducing schizophrenialike symptoms 3monthold C57BL/6J mice received daily injections of PCP 20 mg/kg ip or saline for one week PCPinjected mice produced schizophrenialike behaviours including impaired spatial shortterm memory assessed by the Ymaze task and sensorimotor gating deficits in a prepulse inhibition task Simultaneously chronic PCP administration induced astrocyte and microglial activation in both the cortex and hippocampus Additionally the proinflammatory cytokine interleukin1β was significantly upregulated in PCP administrated mice Furthermore PCP treatment decreased ratio of the phosphoSer9 epitope of glycogen synthase kinase3β GSK3β over total GSK3β which is indicative of increased GSK3β activity These data demonstrate that chronic PCP in mouse produces inflammatory responses and GSK3β activation
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