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Title of Journal: Neurochem Res

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Abbravation: Neurochemical Research

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Springer US

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DOI

10.1007/bf00128606

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ISSN

1573-6903

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Relationship of Adult Neurogenesis with Tau Phosph

Authors: XiaoPing Hong CaiXia Peng Wei Wei Qing Tian YingHua Liu FuYuan Cao Qun Wang JianZhi Wang
Publish Date: 2010/11/09
Volume: 36, Issue: 2, Pages: 288-296
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Abstract

Altered neurogenesis has been reported in Alzheimer disease AD the most common neurodegenerative disorder characterized with hyperphosphorylated tau and accumulation of βamyloid Aβ Recent studies suggest that tau phosphorylation is essential for hippocampal neurogenesis however it is not known whether tau phosphorylation also play a role in neurogenesis of subventricular zone SVZ another main progenitor niche in the brain Here we examined the expression of phosphorylated tau ptau in SVZ and analyzed the role of ptau in adult SVZ neurogenesis We found that the expression of ptau increased during postnatal development and remains at a high level until adulthood and the ptau was colocalized with some SVZ neural precursors However upregulating glycogen synthase kinase3 GSK3 a crucial tau kinase had no effect on SVZ neurogenesis in adult rat brain The SVZ neurogenesis was also unaffected in tau knockout and human tau transgenic mice These results suggest that tau phosphorylation and GSK3 activation may not be essential for adult SVZ neurogenesis

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