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Title of Journal: Neurochem Res

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Abbravation: Neurochemical Research

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Springer US

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DOI

10.1007/BF03321850

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ISSN

1573-6903

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Role of Tuberin in Neuronal Degeneration

Authors: Samy L Habib David Michel Eliezer Masliah Bobby Thomas Han Seok Ko Ted M Dawson Hanna Abboud Robert A Clark Syed Z Imam
Publish Date: 2008/03/05
Volume: 33, Issue: 6, Pages: 1113-1116
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Abstract

One of the tuberous sclerosis complex TSC gene products tuberin is assumed to be the functional component being involved in a wide variety of cellular processes Here we report for the first time that tuberin dysfunction may represent a mechanism for neuronal damage in Alzheimer’s disease AD Parkinson’s disease with dementia PD/DLB and a mouse model of PD Tuberin was hyperphosphorylated at Thr1462 in postmortem frontal cortex tissue of both AD and PD/DLB patients and in mice treated with 1methyl4phenyl1236tetrahydropyridine hydrochloride MPTP Both PTEN and Akt phosphoactivation corresponded to the hyperphosphorylation patterns of tuberin suggesting that the PTEN–Akt pathway might be the mechanism of tuberin phosphorylation Our data provide new information regarding the possible role of tuberin dysfunction in major neurodegenerative disorders such as AD and PD whereby inhibition of tuberin function may trigger an onset of neuronal cell deathThis work was supported in part by NIH grants NS38377 and NS48206 and grants from American Diabetes Association ADA US Dept of Veterans Affairs VA American Parkinson’s Disease Association APDA Parkinson’s Disease Foundation PDF San Antonio Area Foundation SAAF and Executive Research Council ERC of UTHSCSA TMD is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases

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