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Title of Journal: Neurochem Res

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Abbravation: Neurochemical Research

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Springer US

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DOI

10.1006/prep.1996.0025

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ISSN

1573-6903

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Salvianolic Acid A Exerts Antiamnesic Effect on Di

Authors: T Wang S Y Shan B Han L M Zhang F H Fu
Publish Date: 2010/09/30
Volume: 36, Issue: 1, Pages: 103-108
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Abstract

Benzodiazepine was known to produce amnesia Salvianolic acid A extracted from Salvia miltiorrhiza was an effective antioxidant The objective of the study was to evaluate the effect of salvianolic acid A on diazepaminduced amnesia in mice C57BL/6 mice were treated with salvianolic acid A at doses of 10 20 and 40 mg/kg following administration with diazepam at a dose of 3 mg/kg Morris water maze was performed to evaluate the effect of salvianolic acid A on amnesia The antioxidative parameters in hippocampus were measured The results showed that salvianolic acid A decreased the mean escape latency and increased the percentage of time spent in target quadrant Salvianolic acid A reduced the content of malondialdehyde and increased the activities of superoxide dismutase catalase and glutathione peroxidase in hippocampus The findings demonstrated that salvianolic acid A had antiamnesic effects on diazepaminduced anterograde amnesia in mice by augmenting the antioxidative capacity of hippocampus

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