Journal Title
Title of Journal: Neurochem Res
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Abbravation: Neurochemical Research
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Authors: Wei Rong Jun Wang Xiaoguang Liu Liang Jiang Feng Wei Xing Hu Xiaoguang Han Zhongjun Liu
Publish Date: 2012/03/28
Volume: 37, Issue: 8, Pages: 1615-1623
Abstract
The aim of this study was to determine the therapeutic efficacy of starting naringin treatment 1 day after spinal cord injury SCI in rat and to investigate the underlying mechanism SCI was induced using the modified weightdrop method in Sprague–Dawley rats The SCI animals were randomly divided into three groups vehicletreated group 20 mg/kg naringintreated group 40 mg/kg naringintreated group and additionally with sham group laminectomy only Locomotors functional recovery was assessed during the 6 weeks post operation period by performing openfield locomotors tests and inclinedplane tests At the end of the study the segments of spinal cord encompassing the injury site were removed for histopathological analysis Immunohistochemistry was performed to observe the expression of the brainderived neurotrophic factor BDNF The expression of vascular endothelial growth factor VEGF Bcell CLL/lymphoma2 Bcl2 BCL2associated X protein Bax and caspase3 were detected by Western blot analysis The apoptotic neural cells were assessed using the TUNEL method The results showed that the naringintreated animals had significantly better locomotor function recovery less myelin loss and higher expression of BDNF and VEGF In addition naringin treatment significantly increased in Bcl2Bax ratio reduced the enzyme activity of caspase3 and decreased the number of apoptotic cells after SCI These findings suggest that naringin treatment starting 1 day after SCI can significantly improve locomotor recovery and this neuroprotective effect may be related to the upregulation of BDNF and VEGF and the inhibition of neural apoptosis Therefore naringin may be useful as a promising therapeutic agent for SCI
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