Authors: Dan Lv Qian Shi Jiane Liu Aifeng Zhang Fengqin Miao Youji He Yuqing Shen Jianqiong Zhang
Publish Date: 2013/11/24
Volume: 39, Issue: 1, Pages: 180-186
Abstract
The major histocompatibility complex MHC class I molecules are considered to be important in the immune system However the results reported in the past decade indicate that they also play important roles in the central nervous system Here we examined the expression of MHC I and β2microglobulin β2m in human and mouse cerebellar cortex The results show that MHC I molecules are expressed both in human and mouse cerebellar cortex during brain development The expression of H2Kb/Db is gradually increased with the development of mouse cerebellar cortex but finally decreased to a very low level Similarly the expression of HLAB/C genes is increased in developing human cerebellar cortex but decreased after birth The spatial and temporal expression of β2m overlaps mostly with that of HLAB/C molecules and they are coexpressed in Purkinje cells Our findings provide a fundamental basis to reveal the functions of neuronal MHC class I molecules in the development of human cerebellum
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