Authors: M Nakao A Karashima N Katayama
Publish Date: 2007/03/15
Volume: 64, Issue: 10, Pages: 1236-
Abstract
Studies of regulatory mechanisms of sleepwake rhythms have benefited greatly from mathematical modeling There are two major frameworks of modeling one integrates homeostatic and circadian regulations and the other consists of multiple interacting oscillators In this article model constructions based on these respective frameworks and their characteristics are reviewed The twoprocess model and the multioscillator model are explained in detail An appropriate mathematical abstraction is also shown to provide a viewpoint unifying the model structures which might seem to be distinct Recently acquired knowledge of neural regulatory mechanisms of sleepwake rhythm has prompted modeling at the neural network level Such a detailed model is also reviewed and could be used to explore a possible neural mechanism underlying a pathological state of sleepwake rhythm
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