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Title of Journal: Cell Mol Life Sci

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Abbravation: Cellular and Molecular Life Sciences

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Publisher

Springer Basel

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DOI

10.1007/bf02909458

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1420-9071

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Role of NMDA receptors in adult neurogenesis an o

Authors: JeanClaude Platel Wolfgang Kelsch
Publish Date: 2013/02/09
Volume: 70, Issue: 19, Pages: 3591-3601
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Abstract

It is now widely accepted that neurogenesis continues throughout life Accumulating evidence suggests that neurotransmitters are essential signaling molecules that control the different steps of neurogenesis Nevertheless we are only beginning to understand the precise role of neurotransmitter receptors and in particular excitatory glutamatergic transmission in the differentiation of adultborn neurons Recent technical advances allow singlecell gene deletion to study cellautonomous effects during the maturation of adultborn neurons Singlecell gene deletion overcomes some of the difficulties in interpreting global gene deletion effects on entire brain areas or systemic pharmacological approaches that might result in compensatory circuit effects The aim of this review is to summarize recent advances in the understanding of the role of NMDA receptors NMDARs during the differentiation of adultborn neurons and put them in perspective with previous findings on cortical development

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