Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Cell Mol Life Sci

Search In Journal Title:

Abbravation: Cellular and Molecular Life Sciences

Search In Journal Abbravation:

Publisher

SP Birkhäuser Verlag Basel

Search In Publisher:

DOI

10.1007/bf00229511

Search In DOI:

ISSN

1420-9071

Search In ISSN:
Search In Title Of Papers:

Galanin – 25 years with a multitalented neuropepti

Authors: S E Counts S E Perez E J Mufson
Publish Date: 2008/05/27
Volume: 65, Issue: 12, Pages: 1842-1853
PDF Link

Abstract

Galanin GAL and GAL receptors GALRs are overexpressed in degenerating brain regions associated with cognitive decline in Alzheimer’s disease AD The functional consequences of GAL plasticity in AD are unclear GAL inhibits cholinergic transmission in the hippocampus and impairs spatial memory in rodent models suggesting GAL overexpression exacerbates cognitive impairment in AD By contrast gene expression profiling of individual cholinergic basal forebrain CBF neurons aspirated from AD tissue revealed that GAL hyperinnervation positively regulatesmRNAs that promote CBF neuronal function and survival GAL also exerts neuroprotective effects in rodent models of neurotoxicity These data support the growing concept that GAL overexpression preserves CBF neuron function which in turn may slow the onset of AD symptoms Further elucidation of GAL activity in selectively vulnerable brain regions will help gauge the therapeutic potential of GALR ligands for the treatment of AD Part of a Multiauthor Review

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Diabetes propels the risk for cardiovascular disease: sweet monocytes becoming aggressive?
  2. Chemical chaperone therapy for G M1 -gangliosidosis
  3. Deimination is regulated at multiple levels including auto-deimination of peptidylarginine deiminases
  4. d -Ribosylated Tau forms globular aggregates with high cytotoxicity
  5. Next-generation molecular diagnosis: single-cell sequencing from bench to bedside
  6. The mechanism of glutamine-dependent amidotransferases
  7. The mechanism of glutamine-dependent amidotransferases
  8. Tumor-derived exosomes in oncogenic reprogramming and cancer progression
  9. The NF-κB signaling pathway in human genetic diseases
  10. Iron transport across the blood–brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy
  11. Role of NMDA receptors in adult neurogenesis: an ontogenetic (re)view on activity-dependent development
  12. Today’s and tomorrow’s imaging and circulating biomarkers for pulmonary arterial hypertension
  13. Inflammation and immune system interactions in atherosclerosis
  14. A researcher’s guide to the galaxy of IRESs
  15. Molecular dialogue between the human gut microbiota and the host: a Lactobacillus and Bifidobacterium perspective
  16. Development and pathologies of the arterial wall
  17. Role of protein-tyrosine phosphatases in regulation of osteoclastic activity
  18. Axon guidance at the central nervous system midline
  19. Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway
  20. Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akt transduction pathway
  21. When a theory of aging ages badly
  22. Immunophilins: for the love of proteins
  23. Immunophilins: for the love of proteins
  24. Helix insertion into bilayers and the evolution of membrane proteins
  25. Chromogranin A: a novel susceptibility gene for essential hypertension
  26. RETRACTED ARTICLE: Regulation of estrogen receptor signaling in breast carcinogenesis and breast cancer therapy
  27. δ-Opioid receptors protect from anoxic disruption of Na + homeostasis via Na + channel regulation
  28. δ-Opioid receptors protect from anoxic disruption of Na + homeostasis via Na + channel regulation
  29. Trafficking and stability of voltage-gated calcium channels
  30. Translating tissue-engineered tracheal replacement from bench to bedside
  31. Introduction: genetic determinants of mid- and late-life dementias
  32. Activation of cytotoxic T cells by solid tumours?
  33. New perspectives on the role of the fibroblast growth factor family in amphibian development
  34. Lipid sensing and lipid sensors
  35. A Lifetime of Metabolism
  36. The interface of protein-protein complexes: Analysis of contacts and prediction of interactions
  37. Formation and role of exosomes in cancer
  38. Molecular models of the open and closed states of the whole human CFTR protein
  39. Cyclotides: macrocyclic peptides with applications in drug design and agriculture
  40. Epigenetic landscape required for placental development
  41. siRNA-mediated knock-down of NOX3: therapy for hearing loss?
  42. Hypoxia-regulated mechanisms in the pathogenesis of obesity and non-alcoholic fatty liver disease
  43. Spotlight on post-transcriptional control in the circadian system
  44. Senescence suppressors: their practical importance in replicative lifespan extension in stem cells
  45. Protein profiling of genomic instability in endometrial cancer
  46. Human Genome and Diseases:¶Double-strand breaks and translocations in cancer
  47. Interaction of galectin-1 with caveolae induces mouse embryonic stem cell proliferation through the Src, ERas, Akt and mTOR signaling pathways
  48. Mitochondrial control of caspase-dependent and -independent cell death
  49. Mathematical models of regulatory mechanisms of sleep-wake rhythms
  50. Selective effect of burn injury on splenic CD11c + dendritic cells and CD8α + CD4 − CD11c + dendritic cell subsets
  51. Endogenous retroviruses
  52. Apolipoprotein CIII hyperactivates β cell Ca V 1 channels through SR-BI/β1 integrin-dependent coactivation of PKA and Src
  53. Bidirectional actin transport is influenced by microtubule and actin stability
  54. Vaspin inhibits kallikrein 7 by serpin mechanism
  55. Transcription factor Snail is a novel regulator of adipocyte differentiation via inhibiting the expression of peroxisome proliferator-activated receptor γ
  56. Pre-messenger RNA processing and its regulation: a genomic perspective
  57. Specification of neuronal and glial subtypes from human pluripotent stem cells
  58. Organization of microtubule assemblies in Dictyostelium syncytia depends on the microtubule crosslinker, Ase1
  59. The dual role model for p53 in maintaining genomic integrity
  60. Lipid sensing and lipid sensors
  61. Breast cancer stem cell: the roles and therapeutic implications
  62. Fast-folding proteins under stress
  63. Prevention or acceleration of type 1 diabetes by viruses
  64. Neutrophil uptake of nitrogen-bisphosphonates leads to the suppression of human peripheral blood γδ T cells
  65. Studying non-alcoholic fatty liver disease with zebrafish: a confluence of optics, genetics, and physiology
  66. Familial hypobetalipoproteinemia: genetics and metabolism
  67. Fatigue in neuromuscular disorders: focus on Guillain–Barré syndrome and Pompe disease
  68. The multifaceted role of glial cells in amyotrophic lateral sclerosis
  69. Recent advances in the genetics of schizophrenia
  70. Oxidative stress triggers neuronal caspase-independent death: Endonuclease G involvement in programmed cell death-type III
  71. Transcription factor-based modulation of neural stem cell differentiation using direct protein transduction
Search Result: