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Title of Journal: Cell Mol Life Sci

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Abbravation: Cellular and Molecular Life Sciences

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Springer Basel

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DOI

10.1002/chin.198722340

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1420-9071

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Fastfolding proteins under stress

Authors: Kapil Dave Martin Gruebele
Publish Date: 2015/08/01
Volume: 72, Issue: 22, Pages: 4273-4285
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Abstract

Proteins are subject to a variety of stresses in biological organisms including pressure and temperature which are the easiest stresses to simulate by molecular dynamics We discuss the effect of pressure and thermal stress on veryfastfolding model proteins whose in vitro folding can be fully simulated on computers and compared with experiments We then discuss experiments that can be used to subject proteins to low and hightemperature unfolding as well as low and highpressure unfolding Pressure and temperature are prototypical perturbations that illustrate how close many proteins are to instability a property that cells can exploit to control protein function We conclude by reviewing some recent incell experiments and progress being made in simulating and measuring protein stability and function inside live cells

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