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Title of Journal: Cell Mol Life Sci

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Abbravation: Cellular and Molecular Life Sciences

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Springer Basel

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DOI

10.1007/bf00281162

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1420-9071

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Bidirectional actin transport is influenced by mic

Authors: Joshua Chetta James M Love Brian G Bober Sameer B Shah
Publish Date: 2015/06/05
Volume: 72, Issue: 21, Pages: 4205-4220
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Abstract

Local and longdistance transport of cytoskeletal proteins is vital to neuronal maintenance and growth Though recent progress has provided insight into the movement of microtubules and neurofilaments mechanisms underlying the movement of actin remain elusive in large part due to rapid transitions between its filament states and its diverse cellular localization and function In this work we integrated live imaging of rat sensory neurons image processing multiple regression analysis and mathematical modeling to perform the first quantitative highresolution investigation of GFPactin identity and movement in individual axons Our data revealed that filamentous actin densities arise along the length of the axon and move short but significant distances bidirectionally with a net anterograde bias We directly tested the role of actin and microtubules in this movement We also confirmed a role for actin densities in extension of axonal filopodia and demonstrated intermittent correlation of actin and mitochondrial movement Our results support a novel mechanism underlying slow component axonal transport in which the stability of both microtubule and actin cytoskeletal components influence the mobility of filamentous actin

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