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Title of Journal: Cell Mol Life Sci

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Abbravation: Cellular and Molecular Life Sciences

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SP Birkhäuser Verlag Basel

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DOI

10.1016/0006-8993(92)91143-3

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ISSN

1420-9071

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Trafficking and stability of voltagegated calcium

Authors: Brett A Simms Gerald W Zamponi
Publish Date: 2011/10/02
Volume: 69, Issue: 6, Pages: 843-856
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Abstract

Voltagegated calcium channels are important mediators of calcium influx into electrically excitable cells The amount of calcium entering through this family of channel proteins is not only determined by the functional properties of channels embedded in the plasma membrane but also by the numbers of channels that are expressed at the cell surface The trafficking of channels is controlled by numerous processes including coassembly with ancillary calcium channel subunits ubiquitin ligases and interactions with other membrane proteins such as G protein coupled receptors Here we provide an overview about the current state of knowledge of calcium channel trafficking to the cell membrane and of the mechanisms regulating the stability and internalization of this important ion channel familyWork from our laboratory that we discussed here was supported by the Canadian Institutes of Health Research the Natural Sciences and Engineering Research Council and the Heart of Stroke Foundation of Alberta and the Northwest Territories BAS is supported by a studentship from Alberta InnovatesHealth Solutions AIHS GWZ is an AIHS Scientist and a Canada Research Chair

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