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Title of Journal: Cell Mol Life Sci

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Abbravation: Cellular and Molecular Life Sciences

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SP Birkhäuser Verlag Basel

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DOI

10.1002/chin.199210156

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1420-9071

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Selective effect of burn injury on splenic CD11cS

Authors: Julie Patenaude Michele D’Elia Claudine Hamelin Jacques Bernier
Publish Date: 2010/01/20
Volume: 67, Issue: 8, Pages: 1315-1329
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Abstract

Burn injury causes an immunosuppression associated with suppressed adaptive immune function Dendritic cells DCs are APCs for which signaling via their Tolllike receptors TLRs induces their maturation and activation which is essential for the adaptive immune response In this study we examined if burn injury alters the TLR activity of splenic DCs After injury we noticed that DC functions were impaired characterized by a suppressed capacity to prime naive T cells when triggering the TLR4 signaling cascade using specific ligands LPS or rHSP60 The observed perturbations on LPSprimed DCs isolated from burned mice exhibited significantly diminished IL12p40 production and enhanced IL10 secretionassociated impairment in mitogenactivated protein kinase activation Interestingly we observed a decrease of TLR4/MD2 expression on the CD8α+ DC subset that persisted following LPS stimulation The altered TLR4 expression on LPSstimulated CD8α+ DCs was associated with reduced capacity to produce IL12 after stimulation Our results suggested that TLR4 reactivity on DCs especially CD8α+ DCs is disturbed after burn injury

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