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Title of Journal: Cell Mol Life Sci

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Abbravation: Cellular and Molecular Life Sciences

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SP Birkhäuser Verlag Basel

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DOI

10.1016/0192-0561(80)90144-7

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ISSN

1420-9071

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Protein profiling of genomic instability in endome

Authors: Timo Gemoll Jens K Habermann Johanna Lahmann Silke Szymczak Caroline Lundgren Nana K Bündgen Thomas Jungbluth Britta Nordström Susanne Becker Marta I Lomnytska HansPeter Bruch Andreas Ziegler Ulf Hellman Gert Auer Uwe J Roblick Hans Jörnvall
Publish Date: 2011/07/08
Volume: 69, Issue: 2, Pages: 325-333
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Abstract

DNA aneuploidy has been identified as a prognostic factor in the majority of epithelial malignancies We aimed at identifying ploidyassociated protein expression in endometrial cancer of different prognostic subgroups Comparison of gel electrophoresisbased protein expression patterns between normal endometrium n = 5 diploid n = 7 and aneuploid n = 7 endometrial carcinoma detected 121 ploidyassociated protein forms 42 differentially expressed between normal endometrium and diploid endometrioid carcinomas 37 between diploid and aneuploid endometrioid carcinomas and 41 between diploid endometrioid and aneuploid uterine papillary serous cancer Proteins were identified by mass spectrometry and evaluated by Ingenuity Pathway Analysis Targets were confirmed by liquid chromatography/mass spectrometry Mass spectrometry identified 41 distinct polypeptides and pathway analysis resulted in highranked networks with vimentin and NfκB as central nodes These results identify ploidyassociated protein expression differences that overrule histopathologyassociated expression differences and emphasize particular protein networks in genomic stability of endometrial cancer

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