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Title of Journal: Cell Mol Life Sci

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Abbravation: Cellular and Molecular Life Sciences

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Birkhäuser-Verlag

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1420-9071

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Interaction of galectin1 with caveolae induces mo

Authors: M Y Lee S H Lee J H Park H J Han
Publish Date: 2009/03/09
Volume: 66, Issue: 8, Pages: 1467-1478
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Abstract

Galectins have the potential to provide a promising alternative for unveiling the complexity of embryonic stem ES cell selfrenewal although the mechanism by which galectins maintain ES cell selfrenewal has yet to be identified Galectin1 increased 3Hthymidine incorporation as well as cyclin expression and decreased p27kip1 expression Src and caveolin1 phosphorylation was increased by galectin1 and phosphocaveolin1 was inhibited by PP2 In addition inhibition of caveolin1 by small interfering RNA and methylβcyclodextrin MβCD decreased galectin1induced cyclin expression and 3Hthymidine incorporation Galectin1 caused Akt and mTOR phosphorylation which is involved in cyclin expression Galectin1induced phosphoAkt and mTOR was inhibited by PP2 ERas siRNA caveolin1 siRNA and MβCD Furthermore mTOR phosphorylation was decreased by LY294002 and Akt inhibitor Galectin1induced increase in cyclin expression and decrease in p27kip1 was blocked by Akt inhibitor and rapamycin In conclusion galectin1 increased DNA synthesis in mouse ES cells via Src caveolin1 Akt and mTOR signaling pathways

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