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Title of Journal: Cell Mol Life Sci

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Abbravation: Cellular and Molecular Life Sciences

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SP Birkhäuser Verlag Basel

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DOI

10.1007/bf03050126

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1420-9071

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Prevention or acceleration of type 1 diabetes by v

Authors: Liana Ghazarian Julien Diana Yannick Simoni Lucie Beaudoin Agnès Lehuen
Publish Date: 2012/07/06
Volume: 70, Issue: 2, Pages: 239-255
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Abstract

Type 1 diabetes is an autoimmune disease characterized by the destruction of insulinproducing pancreatic βcells Even though extensive scientific research has yielded important insights into the immune mechanisms involved in pancreatic βcell destruction little is known about the events that trigger the autoimmune process Recent epidemiological and experimental data suggest that environmental factors are involved in this process In this review we discuss the role of viruses as an environmental factor on the development of type 1 diabetes and the immune mechanisms by which they can trigger or protect against this pathologyWe apologize to all the authors whose work we could not cite owing to space constrictions This work was supported by funds from the Institut National de la Santé et de la Recherche Médicale and the Centre National pour la Recherche Scientifique grant from ANR09GENO023 and LABEX INFLAMEX to AL Liana Ghazarian and Yannick Simoni were supported by doctoral fellowships from the Ministère de lEducation Nationale et de la Recherche et Technique and from Région ÎledeFrance

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