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Title of Journal: Cell Mol Life Sci

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Abbravation: Cellular and Molecular Life Sciences

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SP Birkhäuser Verlag Basel

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DOI

10.1016/0009-2509(65)85020-5

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1420-9071

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δOpioid receptors protect from anoxic disruption

Authors: Xuezhi Kang Dongman Chao Quanbao Gu Guanghong Ding Yingwei Wang Gianfranco Balboni Lawrence H Lazarus Ying Xia
Publish Date: 2009/09/11
Volume: 66, Issue: 21, Pages: 3505-3516
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Abstract

Hypoxic/ischemic disruption of ionic homeostasis is a critical trigger of neuronal injury/death in the brain There is however no promising strategy against such pathophysiologic change to protect the brain from hypoxic/ischemic injury Here we present a novel finding that activation of δopioid receptors DOR reduced anoxic Na+ influx in the mouse cortex which was completely blocked by DOR antagonism with naltrindole Furthermore we coexpressed DOR and Na+ channels in Xenopus oocytes and showed that DOR expression and activation indeed play an inhibitory role in Na+ channel regulation by decreasing the amplitude of sodium currents and increasing activation threshold of Na+ channels Our results suggest that DOR protects from anoxic disruption of Na+ homeostasis via Na+ channel regulation These data may potentially have significant impacts on understanding the intrinsic mechanism of neuronal responses to stress and provide clues for better solutions of hypoxic/ischemic encephalopathy and for the exploration of acupuncture mechanism since acupuncture activates opioid systemThe data of this manuscript were submitted on May 23 2008 to The Beijing Joint Conference of Physiological Science 2008 and published in the format of abstract Acta Physiologica Sinica 60 Supplement 1 and also presented at the Third Workshop on Scientific Approaches to Chinese Medicine in October 2008

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