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Title of Journal: Cell Mol Life Sci

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Abbravation: Cellular and Molecular Life Sciences

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Publisher

SP Birkhäuser Verlag Basel

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DOI

10.1016/0022-4731(83)91970-2

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ISSN

1420-9071

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Spotlight on posttranscriptional control in the c

Authors: Dorothee Staiger Tino Köster
Publish Date: 2010/08/30
Volume: 68, Issue: 1, Pages: 71-83
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Abstract

An endogenous timing mechanism the circadian clock causes rhythmic expression of a considerable fraction of the genome of most organisms to optimally align physiology and behavior with their environment Circadian clocks are selfsustained oscillators primarily based on transcriptional feedback loops and posttranslational modification of clock proteins It is increasingly becoming clear that regulation at the RNA level strongly impacts the cellular circadian transcriptome and proteome as well as the oscillator mechanism itself This review focuses on posttranscriptional events discussing RNAbinding proteins that by influencing the timing of premRNA splicing polyadenylation and RNA decay shape rhythmic expression profiles Furthermore recent findings on the contribution of microRNAs to orchestrating circadian rhythms are summarized

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