Authors: Robert Renthal
Publish Date: 2009/12/29
Volume: 67, Issue: 7, Pages: 1077-1088
Abstract
Polytopic αhelical membrane proteins cannot spontaneously insert into lipid bilayers without assistance from polytopic αhelical membrane proteins that already reside in the membrane This raises the question of how these proteins evolved Our current knowledge of the insertion of αhelices into natural and model membranes is reviewed with the goal of gaining insight into the evolution of membrane proteins Topics include translocondependent membrane protein insertion antibiotic peptides and proteins in vitro insertion of membrane proteins chaperonemediated insertion of transmembrane helices and Cterminal tailanchored TA proteins Analysis of the E coli genome reveals several predicted Cterminal TA proteins that may be descendents of proteins involved in precellular membrane protein insertion Mechanisms of pretranslocon polytopic αhelical membrane protein insertion are discussed
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