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Title of Journal: Cell Mol Life Sci

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Abbravation: Cellular and Molecular Life Sciences

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SP Birkhäuser Verlag Basel

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DOI

10.1016/0004-6981(78)90287-1

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ISSN

1420-9071

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Alphasynuclein elicits glucose uptake and utiliza

Authors: Gerardo RodriguezAraujo Hironori Nakagami Hiroki Hayashi Masaki Mori Tetsuya Shiuchi Yasuhiko Minokoshi Yoshikazu Nakaoka Yoichi Takami Issei Komuro Ryuichi Morishita Yasufumi Kaneda
Publish Date: 2012/11/03
Volume: 70, Issue: 6, Pages: 1123-1133
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Abstract

Insulin is the main glucoregulator that promotes the uptake of glucose by tissues and the subsequent utilization of glucose as an energy source In this paper we describe a novel glucoregulator the alphasynuclein SNCA protein that has previously been linked to Parkinson’s disease Treatment with recombinant SNCA promotes glucose uptake in vitro in preadipocytes and in vivo in the adipose tissues and skeletal muscles of mice through the LPAR2/Gab1/PI3K/Akt pathway these effects occur independently of the insulin receptor This function of SNCA represents a new mechanistic insight that creates novel avenues of research with respect to the process of glucose regulation

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