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Title of Journal: Cell Mol Life Sci

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Abbravation: Cellular and Molecular Life Sciences

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Springer Basel

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DOI

10.1007/s00350-014-3658-7

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ISSN

1420-9071

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Formation and role of exosomes in cancer

Authors: Lindsey T Brinton Hillary S Sloane Mark Kester Kimberly A Kelly
Publish Date: 2014/10/22
Volume: 72, Issue: 4, Pages: 659-671
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Abstract

Exosomes offer new insight into cancer biology with both diagnostic and therapeutic implications Because of their celltocell communication exosomes influence tumor progression metastasis and therapeutic efficacy They can be isolated from blood and other bodily fluids to reveal disease processes occurring within the body including cancerous growth In addition to being a reservoir of cancer biomarkers they can be reengineered to reinstate tumor immunity Tumor exosomes interact with various cells of the microenvironment to confer tumoradvantageous changes that are responsible for stromal activation induction of the angiogenic switch increased vascular permeability and immune escape Exosomes also contribute to metastasis by aiding in the epithelialtomesenchymal transition and formation of the premetastatic niche Furthermore exosomes protect tumor cells from the cytotoxic effects of chemotherapy drugs and transfer chemoresistance properties to nearby cells Thus exosomes are essential to many lethal elements of cancer and it is important to understand their biogenesis and role in cancer

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