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Title of Journal: Cell Mol Life Sci

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Abbravation: Cellular and Molecular Life Sciences

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Birkhäuser-Verlag

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DOI

10.1002/anie.201108287

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1420-9071

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Role of proteintyrosine phosphatases in regulatio

Authors: M HC Sheng KH W Lau
Publish Date: 2009/02/05
Volume: 66, Issue: 11-12, Pages: 1946-1961
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Abstract

Osteoclasts the primary cell type mediating bone resorption are multinucleated giant cells derived from hematopoietic cells of monocytemacrophage lineage Osteoclast activity is in a large part regulated by proteintyrosine phosphorylation While information about functional roles of several proteintyrosine kinases PTK including cSrc in osteoclastic resorption has been accumulated little is known about the roles of proteintyrosine phosphatases PTPs in regulation of osteoclast activity Recent evidence implicates important regulatory roles for four PTPs SHP1 cytPTPε PTPPEST and PTPoc in osteoclasts CytPTPε PTPPEST and PTPoc are positive regulators of osteoclast activity while SHP1 is a negative regulator Of these PTPs in osteoclasts only PTPoc is a positive regulator of cSrc PTK through dephosphorylation of the inhibitory phosphotyrosine527 residue Although some information about mechanisms of action of these PTPs to regulate osteoclast activity is reviewed in this article much additional work is required to provide more comprehensive details about their functions in osteoclasts

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