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Title of Journal: Cell Mol Life Sci

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Abbravation: Cellular and Molecular Life Sciences

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Publisher

Springer Basel

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DOI

10.1007/bf01180237

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ISSN

1420-9071

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Tumorderived exosomes in oncogenic reprogramming

Authors: Sarmad N Saleem Asim B AbdelMageed
Publish Date: 2014/08/26
Volume: 72, Issue: 1, Pages: 1-10
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Abstract

In multicellular organisms effective communication between cells is a crucial part of cellular and tissue homeostasis This communication mainly involves direct cell–cell contact as well as the secretion of molecules that bind to receptors at the recipient cells However a more recently characterized mode of intercellular communication—the release of membrane vesicles known as exosomes—has been the subject of increasing interest and intensive research over the past decade Following the discovery of the exosomemediated immune activation the pathophysiological roles of exosomes have been recognized in different diseases including cancer In this review we describe the biogenesis and main physical characteristics that define exosomes as a specific population of secreted vesicles with a special focus on their role in oncogenic transformation and cancer progression

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