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Title of Journal: Chem Nat Compd

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Abbravation: Chemistry of Natural Compounds

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Springer US

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DOI

10.1007/bf01540435

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ISSN

1573-8388

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Synthesis and antiHIV activity of triterpene 3E

Authors: L A Baltina L A Baltina R M Kondratenko O A Plyasunova S A Nepogodiev R A Field
Publish Date: 2010/08/27
Volume: 46, Issue: 4, Pages: 576-582
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Abstract

A new method for synthesizing triterpene 3Ogalactosides analogs of glycyrrhizic acid GA based on 18βglycyrrhetic acid GLA methyl esters and 1819dehydroGLA using 2346tetraOacetylaDgalactopyranosyl bromide as the glycosyl donor I–Br promoter and 4Å molecular sieves was developed The method could produce primarily 3OαD or βDgalactopyranosides depending on the reaction conditions The 3OαDgalactopyranoside of GLA exhibited an index of selectivity IS 29 times greater than that of GA for inhibition of accumulation of virusspecific protein p24 of HIV1 βDGalactopyranoside of GLA was more cytotoxic for MT4 cells and exhibited weak antiHIV1 activity

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  14. Evaluation of vinasses from sugarcane molasses distillation as a new source of sugarcane wax
  15. Phenolic Compounds from Roots of Lupinus polyphyllus
  16. Preparation of (2′-5′)-oligonucleotides based on 6- N -benzylaminopurineriboside using the Spicaria violacea fungal enzyme complex
  17. Rapid isocratic HPLC analysis of caffeic acid derivatives from Echinacea purpurea cultivated in Iran
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