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Title of Journal: Chem Nat Compd

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Abbravation: Chemistry of Natural Compounds

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Springer US

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DOI

10.1002/jlac.19727560117

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ISSN

1573-8388

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DNAprotector and cytotoxic activity of secoisolar

Authors: O V Stasevich T V Shman S G Mikhalenok V P Kurchenko
Publish Date: 2010/11/06
Volume: 46, Issue: 5, Pages: 704-709
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Abstract

The relationship between the chemical structure and DNAprotector and cytotoxic activities of phenylpropane lignans was studied Analogs were synthesized from the lignan secoisolariciresinol diglucoside SDG isolated from Linum usitatissimum seeds It was shown that SDG derivatives secoisolariciresinol and secoisolariciresinol4′4″diacetate which were not glucosides exhibited greater cytotoxic activity in vitro than the starting lignan The cytotoxicity was slightly elevated upon acetylation of the aglycon phenol hydroxyls whereas the DNAprotector activity decreased substantially The DNAprotector activity of the derivative without the carbohydrate was slightly greater than that of the starting SDG This was explained by binding of free radicals by the butanediol hydroxyls It was proposed that the activity of the cytotoxic derivatives was mediated by induction of apoptosis of the tumor cells

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