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Title of Journal: J Cancer Res Clin Oncol

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Abbravation: Journal of Cancer Research and Clinical Oncology

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Springer-Verlag

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DOI

10.1002/chin.199649191

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1432-1335

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The potential of plasma thrombomodulin as a biomar

Authors: Jian Zhou ZhaoYou Tang Jia Fan ZhiQuan Wu Yuan Ji ShengLong Ye
Publish Date: 2001/07/14
Volume: 127, Issue: 9, Pages: 559-564
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Abstract

Purpose To study the relationship between thrombomodulin TM plasma levels and the formation of portal vein tumor thrombus PVTT in patients with hepatocellular carcinoma HCC Methods Pre andpostoperative plasma TM levels of 45 patients with HCC and six patients with benign liveroccupying lesion were measured by enzymelinked immunosorbent assay ELISA and the expression of TM in human HCC tissues was determined by immunohistochemistry assay Results The preoperative plasma TM level of patients with HCC 102±57 ng/ml was significantly higher than that of those patients with benign liveroccupying lesion 61±22 ng/ml and that of normal controls 57±10 ng/ml respectively P005 The postoperative TM level of 40 patients with HCC whose tumors had been removed decreased significantly than the preoperative TM level 108±53 ng/ml versus 76±42 ng/ml P005 whereas there was no significant difference between the preoperative and postoperative TM level of six patients with benign liveroccupying lesion 61±22 ng/ml versus 59±18 ng/ml P005 The preoperative plasma TM level of patients with single HCC 115±59 ng/ml or no PVTT 114±56 ng/ml was significantly higher than that of those patients with multiple HCC 81±46 ng/ml or PVTT 69±45 ng/ml respectively P005 The preoperative plasma TM level of the patients with HCC tissue that stained positive for TM was significantly higher than those with tissue that stained negative for TM 122±65 ng/ml versus 87±46 ng/ml P005 The postoperative plasma TM level showed no difference between the patients with HCC tissue stained positive and negative for TM 83±41 ng/ml versus 76±44 ng/ml P005 There was also no significant difference between the plasma TM level and other clinicopathological futures Conclusions Plasma TM increases in patients with HCC and can be a biomarker of the formation of PVTT


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