Authors: Cornelia Bachmann Sara Y Brucker Bernhard Kraemer Ralf Rothmund Anette Staebler Falko Fend Diethelm Wallwiener EvaMaria Grischke
Publish Date: 2015/03/05
Volume: 141, Issue: 8, Pages: 1475-1480
Abstract
Ninetyfive consecutive optimally cytoreduced R ≤ 1 cm patients with primary stage IIIc ovarian cancer underwent stagerelated surgery and got adjuvant platinumbased chemotherapy Median followup 535 months All patients got systematic lymphadenectomy On average 247 pelvic and paraaortic lymph nodes were removed per patient range 1–60 nodes Patients were stratified into three groups to evaluate node involvement ratio affected to resected nodes 1 =0 2 0–≤05 0 and ≤50 of affected nodes 3 05–≤1 50 of affected nodes Clinical parameters were retrospectively evaluated Kaplan–Meier survival curve was used to evaluate the prognostic valueMost often serous histology histologic grade 3 and a node ratio 0–≤05 611 were detected Complete cytoreduction R = 0 mm has significant best prognostic impact compared to R 0 mm–1 cm OS p = 0047 PFS p = 000 Node involvement was associated with serous histology and grade 3 Increasing node ratio leads to significant decreased OS p = 0019 and significant best OS was associated with node ratio 0–≤05The goal is optimal cytoreduction in advanced ovarian cancer More extensive lymphadenectomy seems to play an important role in providing an accurate staging and the node ratio might give prognostic information Current prospective studies like the LION study AGOOvar had to investigate if these data have therapeutic implications and may be considered in future stagingThe EditorinChief has decided to retract this article Upon investigation by an independent researcher it has been found that the authors have duplicated data from the following article Role of Pelvic and Paraaortic Lymph Node Metastases in Optimally Cytoreduced Advanced Ovarian Cancer Bachmann C Brucker SY Kraemer B Rothmund R Staebler A Fend F Wallwiener D Grischke EM Anticancer Res 2015 Jun356347984Our investigation of 95 patients has been approved by the appropriate ethics committee and has therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki All persons gave their informed consent prior to their inclusion in the study
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