Authors: Khaled Elsayad Michael Oertel Uwe Haverkamp Hans Theodor Eich
Publish Date: 2017/01/16
Volume: 143, Issue: 5, Pages: 851-859
Abstract
Leukemia cutis LC is a rare clinical presentation of leukemia that is associated with poor prognosisabs To date the value of radiotherapy RT for the treatment of LC remains controversial Therefore the aim of this study was to analyse the effectiveness of various RT doses for LCA total of 36 radiation courses were administered to 13 patients 8 females 5 males with a median age of 41 years range 2–76 Radiation modalities included 32 focal treatments while total skin electron beam therapy was applied to four patients The median RT dose was 27 Gy range 8–34 A complete response rate CRR to RT was achieved for 32/36 89 lesions 100 for AML lesions versus 33 for the other leukemias P 0001 The median duration of local control DOLC for the entire cohort was 38 months range 0–98 while the median survival MS from the time of LC presentation was 13 months range 25–106 The CRR for the LC lesions treated with highdose regimens 26 Gy versus lowdose regimens ≤26 Gy was 95 versus 83 respectively P = 026 and the median DOLC was 44 months versus 10 months respectively P = 0019 AML patients had a better longterm outcome than the other patients according to median DOLC 40 months versus 2 months respectively P 0001 and MS 24 versus 6 months P = 0004 RT was well tolerated without significant adverse eventsA radiation dose ≤26 Gy confer a comparable CRR to highdose regimens and appears to be an effective treatment for controlling LC progression However radiation doses 26 Gy were associated with a longer DOLC LC patients with underlying AML are associated with better outcome compared with other types of leukemiaAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards
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