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Title of Journal: J Cancer Res Clin Oncol

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Abbravation: Journal of Cancer Research and Clinical Oncology

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Springer-Verlag

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DOI

10.1016/0953-5438(95)90819-7

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1432-1335

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Identification of HTA as a novelspecific marker f

Authors: Yan Liu Yuehui Li Fengjie Guo Miao Dai Jiajia Wang Jinyue Hu Guancheng Li
Publish Date: 2010/02/04
Volume: 136, Issue: 8, Pages: 1187-1192
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Abstract

Hepatocellular carcinoma HCC is the most common malignancy in the world especially in China Early diagnosis of new and recurrent hepatocellular carcinoma followed by timely treatment will help decrease mortality Currently biomarkers are not satisfactory Better diagnostic methods are highly demandedIn this study we have used in silico identification and RTPCR test and discovered a hepatoma associated gene HTA Knockdown of endogenous HTA expression was performed by small interfering RNA in malignant hepatocyte HepG2 Then we tested the cell proliferative ability of these cells in vitro and in vivoHTA was expressed specifically in some kinds of tumors but not detected in any normal tissues It was expressed especially high in hepatocellular carcinoma Knockdown of endogenous HTA expression in HepG2 by small interfering RNA attenuated HCC cell growth

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