Authors: Shigeki Suzuki Keiju Aokage Tomoyuki Hishida Junji Yoshida Takeshi Kuwata Chisako Yamauchi Masahiro Tsuboi Genichiro Ishii
Publish Date: 2016/04/25
Volume: 142, Issue: 7, Pages: 1591-1598
Abstract
Interstitial growth IG which is defined as tumor cells continuously growing into the alveolar septa at the tumor periphery was originally reported as a growth pattern of metastatic sarcoma of the lung On the other hand IG in the primary lung cancers has not been well described This study aimed to examine clinicopathological features of primary lung cancer that harbors IGThirtythree cases out of 2558 13 had IG components IG was significantly more associated with positive smoking history advanced pathological stage presence of vascular invasion and pleural invasion Thirtythree IG+ cases include nine pleomorphic carcinoma nine squamous cell carcinoma and eight adenocarcinoma Interestingly nine 24 out of 38 pleomorphic carcinoma specimens had IG components which was a higher rate than any other histological subtypes The IG+ cancers had significantly shorter overall and recurrencefree survival than did the IG− cancersShigeki S declares that he has no conflict of interest Keiju A declares that he has no conflict of interest Tomoyuki H declares that he has no conflict of interest Junji Y declares that he has no conflict of interest Takeshi K declares that he has no conflict of interest Chisako Y declares that she has no conflict of interest Masahiro T declares that he has no conflict of interest Genichiro I declares that he has no conflict of interestAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards
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