Authors: Yingchun Li Chenyu Wang Mengdan Xu Cuicui Kong Aibing Qu Meng Zhang Zhichao Zheng Guirong Zhang
Publish Date: 2017/01/20
Volume: 143, Issue: 5, Pages: 861-871
Abstract
The purpose of this study is to determine the efficacy of adjuvant immunotherapy with autologous cytokineinduced killer CIK for postoperative patients with gastric cancer and to investigate the impacts of the predictors on the efficacy of CIK immunotherapyNinetytwo gastric cancer patients who have accepted radical resection were enrolled The CIK and control groups were established by 11 matching on their baseline As prognosis indicators preoperative blood cell counts the neutrophil/lymphocyte ratio NLR and platelet/lymphocyte ratio PLR were analyzed respectively Statistical analyses were done using IBM SPSS Statistics ver190CIK treatment significantly prolonged diseasefree survival DFS p 005 and there was a tendency of longer overall survival OS in the CIK group p = 0057 Preoperative NLR was an independent prognostic factor for DFS p 005 When patients were classified into low and high NLR groups using the cutoff value of 2995 patients in the low NLR group had a better DFS p 005 Subset analysis showed that CIK immunotherapy significantly prolonged the DFS in the low NLR group p = 0017 but not in the high NLR group p = 0695 except that it did well clearly within 17 months Compared to the low NLR group lymphocyte decreased significantly neutrophil increased steeply and white blood cell WBC elevated subsequently p 0001in all cases in the high NLR groupAdjuvant immunotherapy with the CIK cells prolongs DFS in postoperative patients with gastric cancer and the preoperative NLR is an independent prognostic factor for DFS Low NLR predicts significant benefits from the CIK immunotherapy while high NLR forebodes the requirement of more cycles of CIK treatment or other stronger immunotherapy to improve the survival rate of patients
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