Authors: Mikio Tomida Iwao Mikami Shingo Takeuchi Hitoshi Nishimura Hirohiko Akiyama
Publish Date: 2009/02/26
Volume: 135, Issue: 9, Pages: 1223-
Abstract
We established an ELISA system for NNMT We determined the levels of NNMT and carcinoembryonic antigen CEA in sera of 113 nonsmall cell lung cancer NSCLC patients undergoing surgery and sera of 50 nonneoplastic lung disease patients with chronic obstructive pulmonary disease COPD and of 24 healthy donorsThe serum levels of NNMT were significantly higher in lung cancer patients than in COPD patients and healthy donors The relationship between the specificity and sensitivity of NNMT and CEA measurements for the detection of lung cancer was analyzed by means of receiveroperating characteristic curves The corresponding areas under the curves were 0703 for NNMT and 0621 for CEA indicating slightly better sensitivity of NNMT With 90 specificity the sensitivities of NNMT and CEA as lung cancer markers were 25 and 24 respectively There was no significant correlation between NNMT and CEA Therefore the sensitivity of NSCLC detection at 90 specificity increased from 25 to 32 when NNMT was used in combination with CEA
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