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Title of Journal: J Cancer Res Clin Oncol

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Abbravation: Journal of Cancer Research and Clinical Oncology

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Springer-Verlag

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DOI

10.1007/978-3-662-45123-6_5

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1432-1335

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Allelic loss of 14q32 in the pathogenesis of gastr

Authors: YuanChang Dai ChungLiang Ho YiChang Tsai YungHsiang Hsu YuChuang Chang HsiaoSheng Liu Helen HaiWen Chen NanHaw Chow
Publish Date: 2004/10/21
Volume: 131, Issue: 2, Pages: 94-100
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Abstract

We screened the allelic status on 16 chromosomal arms in a patient with synchronous ampullary carcinoma and gastric cancer but who had no family history of familial cancer syndrome The significance of the shared 14q deletion was examined on clinical cohorts of sporadic gastric n=12 and ampullary n=10 carcinoma respectively Then highdensity allelotype mapping was performed on 14q32 by using 23 microsatellite markers for the synchronous tumorsThe synchronous gastric and ampullary carcinomas had no frameshift mutations in the APC MSH2 MSH3 and MSH6 genes Among the microsatellite markers screened only D14S267 showed identical loss in the synchronous tumors The same allelic loss was also detected in one of ampullary carcinomas 10 and two of gastric cancers 167 Fine mapping of 14q determined a minimally deleted region between D14S65 and D14S1010 17 centiMorgans for the synchronous tumors

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