Authors: Yanqing Wang Shaowei Xie Xun Shangguan Jiahua Pan Yinjie Zhu Zhixiang Xin Fan Xu Xiaoguang Shao Liancheng Fan Jianjun Sha Qiang Liu Baijun Dong Wei Xue
Publish Date: 2017/03/10
Volume: 143, Issue: 7, Pages: 1157-1166
Abstract
To evaluate and compare the efficacy of prostate volume PV transitional zone volume TZV and prostate volume index PVI the ratio of TZV to peripheral zone volume in the identification of men at risk of prostate cancer PCa and highprogression PCa HPPCa at the initial biopsy IBX in a realworld populationFrom Jul 2014 to Aug 2016 data on 1144 patients who had undergone the initial prostate biopsies were prospectively collected and analyzed Univariate and multivariate logistic regression analyses were performed to identify the independent predictors for PCa and HPPCa Based on independent predictors nomogram models were developed and internally validated to assess a man’s risk of harboring PCa and HPPCaThe detection rates of PCa and HPPCa were 4309 493/1144 and 3916 448/1144 respectively In the multivariate analyses age PSA TZV DRE and TRUS instead of PV or PVI were independent predictors for PCa and HPPCa percent free PSA was independent predictor for PCa not for HPPCa Such independent predictors were finally included in the nomogram models The AUCs of TZVbased nomogram models were 870 for PCa and 877 for HPPCa which were higher than that of PSA alone or other predictive modelsThis study was supported by the National Natural Science Foundation of China 81572536 81672850 Science and Technology Commission of Shanghai Municipality 14140901700 16411969800 the Joint Research Foundation for Innovative Medical Technology of Shanghai Shenkang Hospital Development Center SHDC12015125 Shanghai Municipal Education Commission 15ZZ058 Shanghai Municipal Commission of Health and Family Planning 201640247 Shanghai Municipal Education CommissionGaofeng Clinical Medicine Grant Support 20152215 Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai PWZxq201405 the Shanghai Jiao Tong University School of Medicine Translational Research Innovation Fund 15ZH4002 and Incubating Program for clinical Research and Innovation of Renji Hospital Shanghai Jiao Tong University School of Medicine PYZY16008 PYXJS16015This study was approved by the Ethics Committee at the Renji Hospital Shanghai Jiao Tong University School of Medicine All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards
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